Document 0116
 DOCN  M9480116
 TI    Characterization of adherent T cells to human endothelial cells in
       patients with HTLV-I-associated myelopathy.
 DT    9410
 AU    Ichinose K; Nakamura T; Nishiura Y; Nagasato K; Ohishi K; Watanabe H;
       Fujita A; Kurouji K; Tsujihata M; Nagataki S; First Department of
       Internal Medicine, Nagasaki University School; of Medicine, Japan.
 SO    J Neurol Sci. 1994 Apr;122(2):204-9. Unique Identifier : AIDSLINE
       MED/94293035
 AB    To clarify the phenomenon of increased adherence of T cells to
       endothelial cells (EC) in patients with HTLV-I-associated myelopathy
       (HAM), we determined the surface markers and expression of lymphocyte
       function antigen-1 (LFA-1) in T cells adherent or nonadherent to EC. The
       percentage of activated or HLA-DR+ T cells and the expression of LFA-1
       in the adherent cell population were significantly higher than those in
       the nonadherent cell population. Moreover, the CD4 to CD8 ratio of the
       HLA-DR+ cells in the EC-adherent T cells was significantly higher than
       that in the nonadherent cells. Collectively, these results indicate that
       increased adherence of T cells to EC in HAM patients is based on the
       increase of activated T cells with high density LFA-1 expression in the
       peripheral blood. Moreover, CD4+ HLA-DR+ cells exhibited more adhesive
       activity to EC than CD8+ HLA-DR+ cells, suggesting that activated CD4+
       cells, rather than activated CD8+ cells, may be important as the first
       trigger for T cell-infiltration to the central nervous system in the
       immunopathogenesis of HAM.
 DE    Adult  Aged  Antigens, CD/ANALYSIS  Antigens, Differentiation,
       T-Lymphocyte/ANALYSIS  Cell Adhesion  Cells, Cultured  Endothelium,
       Vascular/CYTOLOGY/*METABOLISM  Female  Flow Cytometry  Human  HLA-DR
       Antigens/ANALYSIS  Male  Middle Age  Paraparesis, Tropical
       Spastic/BLOOD/*IMMUNOLOGY  Support, Non-U.S. Gov't  T-Lymphocyte
       Subsets/CHEMISTRY/*METABOLISM  Umbilical Veins  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).